Human leukocyte antigens (HLA) are a system of glycoproteins that have a functional role in the presentation of peptides to the immune system.However, as a highly polymorphic system, HLA molecules can become the targets of antibody responses in people during pregnancy, transfusion of blood products, or organ transplant rejection. Generally, alloimmunization leads to the production of HLA antibodies in approximately 33% of exposed individuals. The presence or absence of these HLA-specific antibodies has a role in determining the survival of transplant allografts.
LIFECODES LifeScreen Deluxe Beads are designed to detect IgG antibodies to HLA Class I and Class II antigens. LifeScreen Deluxe is composed of unique Luminex Beads to which affinity purified Class I HLA and Class II HLA glycoproteins are conjugated.
