nCounter CAR-T Characterization Panel

The CAR-T Characterization Panel is designed for monitoring gene expression throughout the phases of the CAR-T cell therapy development, to guarantee quality and efficacy of the final CAR-T product.

This panel could help you with the automatization of the CAR-T manufacturing workflow and improve reproducibility. You could create the manufacturing acceptance criteria, measure metabolic fitness and persistence, monitor post-infusion exhaustion and toxicity…

It includes 780 genes (request list) relative to the T-cell phenotype, cell types, TCR diversity, T-cell activation, their metabolism, persistence, T-cell exhaustion and toxicity.

For more information about the pathways included in the panel and the immune cell profiling, please, consult the product file you can download below or visit the NanoString web:

Advanced Analysis Modules available for this panel: 

1. Normalization 
2. Quality Control 
3. Pathway Analysis 
4. Cell Profiling 
5. Differential Expression 
6. Gene Set Analysis 
7. Built-in Compatibility for Panel Plus and Protein Analysis 
8. TCR Diversity Score 

Panel Customization

The CAR-T Characterization Panel could be combined with a Panel Plus, which will allow you to add up to 55 genes chosen by the client.

If you want to check that this panel is the most suitable for you, you can go to the NanoString Panel Pro panel selection tool: