CatalogOncologySolid Tumor
The PanCancer Immuno-Oncology 360 Panel is designed for a comprehensive study (360° view) of the impact of immune evasion in the tumor microenvironment, and the identification of potentially prognostic, predictive or mechanism of action signatures for immunotherapy. Furthermore, it includes genes related to the tumor biology, the tumoral microenvironment and the immune response.
It incorporates 48 potentially predictive Research Use Only (RUO) biological signatures including the 18-gene Tumor Inflammation Signature (TIS), which measures a peripherally suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.
It includes 770 genes (request list) involved in 13 key pathways and processes in the tumor biology, microenvironment and immune response.
For more information about the biological signatures, and the pathways and processes included in the panel, please, consult the product file you can download below or visit the NanoString web:
Panel Customization
The PanCancerIO 360 Panel could be combined with a Panel Plus, which will allow you to add up to 55 genes chosen by the client.
If you want to check that this panel is the most suitable for you, you can go to the NanoString Panel Pro panel selection tool:
| Product | Product Description | Quantity | Catalog Number |
|---|---|---|---|
| nCounter Human PanCancer IO 360 Codeset + Panel Standard | Gene Expression CodeSet profiling (770 genes); 750 cancer-related human genes + 20 internal reference controls. The PanCancer IO 360 panel includes a Panel Standard contaning a pool of synthetic DNA oligonucleotides that correspond to the target sequence of each of the 770 unique probe targets in the panel. This allows for normalization for possible user, instrument, and lot-to-lot variation. | 12 Reactions | XT-CSPS-HIO360-12 |
| nCounter Mouse PanCancer IO 360 Codeset + Panel Standard | Gene Expression CodeSet profiling (770 genes); 750 cancer-related mouse genes + 20 internal reference controls. The PanCancer IO 360 panel includes a Panel Standard contaning a pool of synthetic DNA oligonucleotides that correspond to the target sequence of each of the 770 unique probe targets in the panel. This allows for normalization for possible user, instrument, and lot-to-lot variation. | 12 Reactions | XT-CSPS-MIO360-12 |
| nCounter Master Kit | Reagents, cartridges, and consumables necessary for sample processing on nCounter MAX and FLEX Systems | 12 Reactions | NAA-AKIT-012 |
| nCounter SPRINT Cartridge 1 Cartridge, 12 lanes | Sample Cartridge for nCounter SPRINT System | 12 Reactions | SPRINT-CAR-1.0 |
| nCounter SPRINT Reagent Pack | Sample Cartridge for nCounter SPRINT System | 192 Reactions | SPRINT-REAG-KIT |
| Low Input RNA Reagent Kit | 48 reactions kit for profiling from low sample input amounts | 48 Reactions | LOW-RNA-48 |
| Human PanCancer IO 360 Primer Pool | MTE primer pools for Low Input RNA profiling (770 genes); 750 Immune related human genes + 20 internal reference controls. Master Kit, RNA Low Input Kit and Panel CodeSet required | 12 Reactions | PP-HIO360-12 |
| Mouse PanCancer IO 360 Primer Pool | MTE primer pools for Low Input RNA profiling (770 genes); 750 Immune related mouse genes + 20 internal reference controls. Master Kit, RNA Low Input Kit and Panel CodeSet required | 12 Reactions | PP-MIO360-12 |
