The PanCancer Pathways 360 Panel is designed for a comprehensive study (360° view) of major cancer pathways. Furthermore, it includes genes related to the tumor biology, the tumoral microenvironment and the immune response.
This panel could help you with measuring treatment effects on certain pathways and analysing their deregulation, generating follow-up research hypotheses, discovering new biomarkers or investigating drug mechanism of action.
It incorporates the 18-gene Tumor Inflammation Signature (TIS), which measures a peripherally suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.
It includes 770 genes (request list) involved in 13 cancer-associated canonical pathways: Wnt, Hedgehog, apoptosis, cell cycle, RAS, PI3K, STAT, MAPK, Notch, TGF-β, chromatin modification, transcriptional regulation, and DNA damage control.
For more information about the pathways included in the panel, please, consult the product file you can download below or visit the NanoString web:
The PanCancer Pathways 360 Panel could be combined with a Panel Plus, which will allow you to add up to 55 genes chosen by the client.
If you want to check that this panel is the most suitable for you, you can go to the NanoString Panel Pro panel selection tool:
|nCounter PanCancer Pathways Panel||Gene Expression CodeSet profiling (770 genes); 730 cancer-related human genes + 40 internal reference controls. Master Kit reagents sold separately.||XT-CSO-PATH1-1||12 Reactions|
|nCounter PanCancer Mouse Pathways Panel||Gene Expression CodeSet profiling (770 genes); 750 cancer-related mouse genes + 20 internal reference controls. Master Kit reagents sold separately.||XT-CSO-MPATH1-12||12 Reactions|