SOPHiA GENETICS Solid Tumor Solution Kit (STS) is a molecular diagnostic assay designed for the analysis of relevant regions in 42 genes with mutations commonly associated with solid tumors, from DNA extracted from FFPE tissue and liquid biopsy.
In addition, it allows the detection of SNVs and Indels, and also CNV (24 genes).
Example of diseases covered by the panel:
- Lung cancer: BRAF, EGFR, MET, KRAS, ALK, PIK3CA
- Colorectal cancer: BRAF, KRAS, PIK3CA, NRAS
- Skin cancer: GNA11, GNAS, GNAQ
- Cerebral Tumor: TERT promoter, IDH1, IDH2, HIST1H3B, H3F3A, H3F3B
STSplus panel is also available, which includes, in addition to the standard panel, RNA analysis for 137 gene fusions. It also covers 6 unique loci to detect the status of MSI associated with colorectal cancer.
The Solid Tumor Solution Kit (STS) and the STSplus version use NGS capture technology and are intended for use on Illumina platforms. The results are interpreted in the SOPHiA DDM platform, designed for the analysis, storage and protection of NGS clinical data in the routine diagnosis.
In addition to the Solid Tumor Solution, other panels for clinical diagnosis in areas such as metabolism, oncohematology, genetics or cardiology are available.